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What is Premature Ovarian Failure?

27/7/2017

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Premature Ovarian Failure is a condition characterized by amenorrhea (no menses), low estrogen level and high gonadotrophin levels resulting in menopause-like symptoms in women younger than age 40.

The human ovary function as a reproductive organ storing and producing eggs every month during ovulation to enable fertilization by sperm and to facilitate monthly menses. It also acts as endocrine organ producing female hormones estrogen and progesterone which regulates menses. Predictable monthly menses cycle means the ovaries are healthily functioning during the reproductive years.

Usually the pituitary gland will produce gonadotrophins (Follicle Stimulating Hormone FSH & Luteinizing Hormone LH) which regulate the production of female hormones from the ovaries.

Ageing will be associated with decrease fertility due to the reduce number of eggs in the ovary, menstrual irregularity and reduced hormone productions. Finally menopause is when there is irreversible cessation of menses around age 50.

In patients with premature ovarian failure, the ovaries fail to function properly before the age 40. The ovaries are unable to ovulate and produce normal levels of female hormones. This results in infertility, early menopause and increased risk of osteoporosis. The estimated incidence of premature ovarian failure is 1 in 1000 women younger than 30, 1 in 250 in women by age 35 and 1 in 100 in women by age 40.

Read more: http://www.medthical.com/premature-ovarian-failure.html
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